Trans eQTL analysis of milk composition QTL genotype shows limited co associated gene expression networksUnlike the DGAT1 and AGPAT6 fatty acid synthesis enzymes that underlie other major milk production QTLs4,7, the mechanistic explanation for the impact of MGST1 on these traits is unclear. The MGST1 gene encodes a glutathione S transferase that protects against oxidative stress, responsible for conjugation of glutathione to reactive intermediates. The enzyme is localised to the mitochondrial membrane and endoplasmic reticulum, and known functions include aspects of lipid biology, where MGST1 has been shown to reduce lipid peroxidation products in human mammary cell culture26.
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